Mike or Michael Pyle may refer to:
- Michael Pyle (BlackRock), chief investment strategist (BlackRock), Kamala Harris’s chief economist (Biden administration)
- Mike Pyle (American football) (1939–2015), American football player
- Mike Pyle (fighter) (born 1975), American mixed martial arts fighter
See also
- Robert Michael Pyle (born 1947), American lepidopterist and writer