Sophia Smith may refer to:
- Sophia Smith (soccer, born 2000), American footballer
- Sophia Smith (footballer, born 1978), American-Greek footballer
- Sophia Smith (Smith College) (1796–1870), founder of Smith College
- Sophia Smith Collection, repository of manuscripts, photographs, periodicals and other primary sources in women's history
See also
- Sofia Tekela-Smith (born 1960), New Zealand artist
- Sophie Smith (born 1986), Australian water polo player
- Sophie Smith (journalist) (born 1986), Australian journalist