Born near Paw Paw, Illinois, Guyer attended the public schools, Lane University at Lecompton, Kansas, and the University of Kansas School of Law at Lawrence, Kansas. He was admitted to the bar in 1902 and commenced practice in Kansas City, Kansas. He served as judge of the first division city court of Kansas City from 1907-09. He served as mayor of Kansas City, Kansas from 1909 to 1910.
Guyer was elected as a Republican to the Sixty-eighth Congress to fill the vacancy caused by the death of Edward C. Little and served from November 4, 1924, to March 3, 1925. He was not a candidate for election for the full term in 1924. He resumed the practice of law in Kansas City.
He was re-elected to the Seventieth and to the eight succeeding Congresses and served from March 4, 1927, until his death. He was one of the managers appointed by the United States House of Representatives in 1933 to conduct the impeachment proceedings against Harold Louderback, judge of the United States District Court for the Northern District of California. He died in Bethesda, Maryland on June 5, 1943. Among the items in his estate was a 40-volume personal diary he had kept for many years.
- "A 40-Volume Diary Part of Guyer's Estate". The Iola Register. Kansas. 11 June 1943. p. 6.
- United States Congress. "U. S. Guyer (id: G000538)". Biographical Directory of the United States Congress.
This article incorporates public domain material from the Biographical Directory of the United States Congress.