Muskogee or Muscogee can refer to:
- Muscogee, or Muscogee Creek, a Native American people of the southeastern woodlands
- Muscogee (Creek) Nation, a federally recognized Muscogee tribe in Oklahoma
- Muscogee language, a language spoken by some Muscogee and Seminole
- Muskogean languages, a language family including Muscogee
- Muscogee, Florida, a ghost town
- Muskogee, Oklahoma, a city
- Muscogee County, Georgia
- Muskogee County, Oklahoma
- State of Muskogee, a nation declared by William Augustus Bowles in 1799
- The City of Muskogee, a municipal government
- USS Muskogee, a US warship in WW2