The City of New Orleans, also called New Orleans, is the largest city in the U.S. state of Louisiana.
City of New Orleans may also refer to:
- City of New Orleans (train), a passenger train service in the United States.
- "City of New Orleans" (song), by Steve Goodman
- City of New Orleans (album), by Willie Nelson
- The City of New Orleans, a steamboat operated by the Anchor Line on the Mississippi River from 1881 to 1898