Major General James G. Blunt

SDZ SER-082 is a drug which acts as a mixed antagonist for the 5-HT2B and 5-HT2C serotonin receptors, with good selectivity over other serotonin receptor subtypes and slight preference for 5-HT2C over 5-HT2B.[1] It has been used in animal studies into the behavioural effects of the different 5-HT2 subtypes,[2][3][4] and how they influence the effects of other drugs such as cocaine.[5][6][7]

References

  1. ^ Nozulak J, Kalkman HO, Floersheim P, Hoyer D, Schoeffter P, Buerki HR (January 1995). "(+)-cis-4,5,7a,8,9,10,11,11a-octahydro-7H-10-methylindolo[1,7- bc][2,6]-naphthyridine: a 5-HT2C/2B receptor antagonist with low 5-HT2A receptor affinity". Journal of Medicinal Chemistry. 38 (1): 28–33. doi:10.1021/jm00001a007. PMID 7837236.
  2. ^ Mora PO, Netto CF, Graeff FG (December 1997). "Role of 5-HT2A and 5-HT2C receptor subtypes in the two types of fear generated by the elevated T-maze". Pharmacology Biochemistry and Behavior. 58 (4): 1051–7. doi:10.1016/S0091-3057(97)00057-9. PMID 9408213. S2CID 11115355.
  3. ^ Dave KD, Harvey JA, Aloyo VJ (May 2002). "A novel behavioral model that discriminates between 5-HT2A and 5-HT2C receptor activation". Pharmacology Biochemistry and Behavior. 72 (1–2): 371–8. doi:10.1016/S0091-3057(01)00767-5. PMID 11900808. S2CID 36921090.
  4. ^ Hawkins MF, Uzelac SM, Hearn JK, Baumeister AA (October 2008). "Effects of selective serotonin2 ligands on behaviors evoked by stress in the rat". Pharmacology Biochemistry and Behavior. 90 (4): 632–9. doi:10.1016/j.pbb.2008.05.006. PMID 18572227. S2CID 25959070.
  5. ^ Filip M, Bubar MJ, Cunningham KA (September 2004). "Contribution of serotonin (5-hydroxytryptamine; 5-HT) 5-HT2 receptor subtypes to the hyperlocomotor effects of cocaine: acute and chronic pharmacological analyses". The Journal of Pharmacology and Experimental Therapeutics. 310 (3): 1246–54. doi:10.1124/jpet.104.068841. PMID 15131246. S2CID 25809734.
  6. ^ Filip M (2005). "Role of serotonin (5-HT)2 receptors in cocaine self-administration and seeking behavior in rats". Pharmacological Reports. 57 (1): 35–46. PMID 15849375.
  7. ^ Filip M, Bubar MJ, Cunningham KA (January 2006). "Contribution of serotonin (5-HT) 5-HT2 receptor subtypes to the discriminative stimulus effects of cocaine in rats". Psychopharmacology. 183 (4): 482–9. doi:10.1007/s00213-005-0197-y. PMID 16261316. S2CID 23148827.


source: https://en.wikipedia.org/wiki/SDZ_SER-082