Born near Iola, Kansas, Scott attended the common schools. He was graduated from the University of Kansas at Lawrence in 1881. He went to Colorado, New Mexico, and Arizona, and was engaged chiefly in clerical work. He returned to Iola in 1882 and edited the Iola Register. He was appointed regent of the university in 1891–1900. He served as member of the Kansas State Senate from 1892 to 1896, and according to the 1903 Congressional Directory, "at different times has been president of the State Editorial Association, president of the Kansas League of Republican Clubs, and president of the Kansas Day Club, an organization of the young Republicans of the State".
Scott was an unsuccessful candidate for reelection in 1910 to the 62nd Congress. He was appointed one of five delegates to the International Institute of Agriculture at Rome in 1911. He lectured on Chautauqua platform in 1913, 1915, and 1916. He served as delegate to the Republican National Conventions in 1916 and 1932
Scott was an unsuccessful candidate for nomination to the United States Senate in 1918 and again in 1928. He resumed newspaper work until his death in Iola, Kansas, on September 18, 1938. He was interred in Iola Cemetery.
- "S. Doc. 58-1 - Fifty-eighth Congress. (Extraordinary session -- beginning November 9, 1903.) Official Congressional Directory for the use of the United States Congress. Compiled under the direction of the Joint Committee on Printing by A.J. Halford. Special edition. Corrections made to November 5, 1903". GovInfo.gov. U.S. Government Printing Office. November 9, 1903. p. 34. Retrieved July 2, 2023.
- United States Congress. "Charles Frederick Scott (id: S000166)". Biographical Directory of the United States Congress.
- Works by Charles Frederick Scott at Biodiversity Heritage Library
- Works by or about Charles Frederick Scott at Internet Archive
This article incorporates public domain material from the Biographical Directory of the United States Congress.