Crime scene investigation may refer to:
- Crime scene investigation, an important part of forensic science
- CSI: Crime Scene Investigation, a US television series (2000–2015)
- CSI: Crime Scene Investigation (video game), a 2003 video game based on the TV show
- CSI (franchise), a US TV franchise, including CSI (2000–2015)
- CSI Sanatan, a 2023 Indian Telugu-language film by Sivashankar Dev