Colonel William A. Phillips

GR-127935 is a drug which acts as a selective antagonist at the serotonin receptors 5-HT1B and 5-HT1D.[1] It has little effect when given by itself but blocks the antiaggressive effect of 5-HT1B agonists,[2] and alters release of serotonin in the brain,[3] as well as reducing drug-seeking behaviour in cocaine addicted rats.[4]

See also

References

  1. ^ Skingle M, Beattie DT, Scopes DI, Starkey SJ, Connor HE, Feniuk W, Tyers MB (1996). "GR127935: a potent and selective 5-HT1D receptor antagonist". Behavioural Brain Research. 73 (1–2): 157–61. doi:10.1016/0166-4328(96)00089-7. PMID 8788495. S2CID 34394584.
  2. ^ Bannai M, Fish EW, Faccidomo S, Miczek KA (August 2007). "Anti-aggressive effects of agonists at 5-HT1B receptors in the dorsal raphe nucleus of mice". Psychopharmacology. 193 (2): 295–304. doi:10.1007/s00213-007-0780-5. PMID 17440711. S2CID 6766784.
  3. ^ Rex A, Voigt JP, Wicke KM, Fink H (January 2008). "In vivo/ex vivo and behavioural study on central effects of 5-HT1B/1D and 5-HT1A antagonists in guinea pigs". Pharmacology Biochemistry and Behavior. 88 (3): 196–204. doi:10.1016/j.pbb.2007.07.016. PMID 17888505. S2CID 26577695.
  4. ^ Przegaliński E, Gołda A, Filip M (2008). "Effects of serotonin (5-HT)(1B) receptor ligands on cocaine-seeking behavior in rats". Pharmacological Reports. 60 (6): 798–810. PMID 19211971.
source: https://en.wikipedia.org/wiki/GR-127935