Securinine is an alkaloid found in Securinega suffruticosa[1] and Phyllanthus niruri.[2]
Pharmacology
Securinine has pro-convulsant effects[3][4] and it has a strong spastic effect, similar to the actions of strychnine.[5]
Securinine is a GABA-A antagonist.[6][7]
See also
References
- ^ Du GH, Wang DS, Fang LH, Du GH (2018). "Securinine". Natural Small Molecule Drugs from Plants. Springer Singapore. pp. 325–330. doi:10.1007/978-981-10-8022-7_54. ISBN 978-981-10-8021-0.
- ^ Patel JR, Tripathi P, Sharma V, Chauhan NS, Dixit VK (November 2011). "Phyllanthus amarus: ethnomedicinal uses, phytochemistry and pharmacology: a review". Journal of Ethnopharmacology. 138 (2): 286–313. doi:10.1016/j.jep.2011.09.040. PMID 21982793.
- ^ Tao SC, Peng JZ, Lu MW (January 1986). "[Central convulsive action of l-securinine]". Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica. 7 (1): 9–12. PMID 2876581.
- ^ Zhang SC, Li SZ, Gao XC, Qian LH, Yang MZ, Yuan HN, Tan DJ (July 1993). "[The adverse effects of the preparations of the active principles of Chinese herbal drugs]". Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. 18 (7): 387–391. PMID 8267848.
- ^ Klochkov S, Neganova M (May 2021). "Unique indolizidine alkaloid securinine is a promising scaffold for the development of neuroprotective and antitumor drugs". RSC Advances. 11 (31): 19185–19195. Bibcode:2021RSCAd..1119185K. doi:10.1039/D1RA02558A. PMC 9033663. PMID 35478659.
- ^ "Securinine". PubChem, US National Library of Medicine. 2020-07-04.
- ^ Beutler JA, Karbon EW, Brubaker AN, Malik R, Curtis DR, Enna SJ (March 1985). "Securinine alkaloids: a new class of GABA receptor antagonist". Brain Research. 330 (1): 135–140. doi:10.1016/0006-8993(85)90014-9. PMID 2985189. S2CID 21138482.