Battle of Caving Banks

Etidocaine, marketed under the trade name Duranest, is an amide-type local anesthetic given by injection during surgical procedures and labor and delivery. Etidocaine has a long duration of activity, and the main disadvantage of using during dentistry is increased bleeding during surgery.[1]

Synthesis

Patent:[2] 2-bromobutyryl chloride synthesis:[3]

The amide reaction between 2,6-xylidine (1) and 2-bromobutyryl chloride [22118-12-3] (2) gives 2-Bromo-N-(2,6-Dimethylphenyl)Butanamide [53984-81-9] (3). Alkylation with N-Ethylpropylamine [20193-20-8] (4) gives Etidocaine (5).

References

  1. ^ Sisk AL (1992). "Long-acting local anesthetics in dentistry". Anesthesia Progress. 39 (3): 53–60. PMC 2148750. PMID 1308373.
  2. ^ DE2162744 idem H Adams, G Kronberg, B Takman, U.S. patent 3,812,147 (1974 to Astra Pharma Prod).
  3. ^ Org. Synth. 1950, 30, 62. DOI: 10.15227/orgsyn.030.0062

External links

source: https://en.wikipedia.org/wiki/Etidocaine