Mackenzie River may refer to:
Australia
- Mackenzie River (Queensland), a tributary of the Fitzroy River in Queensland
- Mackenzie River (Victoria), in western Victoria, Australia, also called the McKenzie River, a tributary of the Wimmera River
Canada
- Mackenzie River, the longest river in Canada
- Mackenzie River (Nova Scotia)
New Zealand
- Mackenzie River (New Zealand) in the South Island of New Zealand
See also
- McKenzie River (disambiguation)
- SS Mackenzie River (1908), steamship on the Mackenzie River system