Hemendra Nath Chatterjee was an Indian scientist from West Bengal known for the earliest publication of a formula for Orally Rehydrated Saline (ORS) for diarrhea management in 1952.[1][2][3] Although his results were published in The Lancet, they didn't receive much recognition from Western scientists until later.[2] Some argue this was for cultural reasons as his treatment protocol included traditional medicine, and also because the scientific underpinnings of ORS weren't well understood.[2] However, some argue he shouldn't be given credit for its invention at all, as some of his results contradict the results of modern studies, and argue his success was likely due to using only mildly ill patients.[1]
In his 1953 study, Chatterjee gave a dilute salt and glucose solutions both rectally and orally to a small percentage of pre-selected mildly ill cholera patients. He did not measure intake and output and presented no balance dated confirming absorption. In that paper he states that Avomine can stop vomiting during cholera and then oral rehydration is possible. Patients also received a leaf decoction of Coleus aromaticus, a folk anti-diarrheal, which is now known to make diarrhea worse.[1] The formulation of the fluid replacement solution was hypotonic sodium chloride, 25 g of glucose and 1000 ml of water.[3][4]
References
- ^ a b c Nalin, David R. (March 2022). "The History of Intravenous and Oral Rehydration and Maintenance Therapy of Cholera and Non-Cholera Dehydrating Diarrheas: A Deconstruction of Translational Medicine: From Bench to Bedside?". Tropical Medicine and Infectious Disease. 7 (3): 50. doi:10.3390/tropicalmed7030050. ISSN 2414-6366. PMC 8949912. PMID 35324597.
- ^ a b c Matt Reynolds. "Salt, Sugar, Water, Zinc: How Scientists Learned to Treat the 20th Century's Biggest Killer of Children—Asterisk". www.asteriskmag.com. Retrieved 13 April 2023.
- ^ a b Control of vomiting in cholera and oral replacement of fluid; Chatterjee HN; Lancet. 2 November 1953;2(6795):1063 [permanent dead link]
- ^ MAGIC BULLET: THE HISTORY OF ORAL REHYDRATION THERAPY; JOSHUA NALIBOW RUXIN