Contents
Add links
Tools
Actions
General
- What links here
- Related changes
- Upload file
- Special pages
- Permanent link
- Page information
- Cite this page
- Get shortened URL
- Download QR code
- Wikidata item
Print/export
- Download as PDF
- Printable version
Chemical compound
Ethylcholine mustard is a neurotoxic nitrogen mustard that destroys cholinergic neurons.[2][3] It's the hydrolysis product of the HN1 vesicant.[1]
Mechanism of action
Under aqueous condition, ethylcholine mustard forms the highly reactive ethylcholine aziridinium (AF64A) ion. AF64A is transported into cholinergic neurons by the choline transporter. AF64A irreversibly inhibits the choline acetyltransferase and thereby inhibits acetylcholine synthesis. AF64A can also produce cytotoxic effects, leading to cell death.[2][3]
The aziridinium ion can be isolated as picrylsulfonate salt.[1]
See also
References
- ^ a b c "Chemical Warfare Agents, and Related Chemical Problems, Parts III-VI-Summary Technical Report".
- ^ a b Sandberg, K.; Schnaar, R. L.; McKinney, M.; Hanin, I.; Fisher, A.; Coyle, J. T. (February 1985). "AF64A: An Active Site Directed Irreversible Inhibitor of Choline Acetyltransferase". Journal of Neurochemistry. 44 (2): 439–445. doi:10.1111/j.1471-4159.1985.tb05434.x. PMID 3838098. S2CID 10890459.
- ^ a b Colhoun, E.H.; Rylett, R.J. (January 1986). "Nitrogen mustard analogues of choline: potential for use and misuse". Trends in Pharmacological Sciences. 7: 55–58. doi:10.1016/0165-6147(86)90253-1.
Enzyme (modulators) |
| ||||||
---|---|---|---|---|---|---|---|
Transporter (modulators) |
| ||||||
Release (modulators) |
| ||||||
Animal toxins | |
---|---|
Bacterial | |
Cyanotoxins | |
Plant toxins | |
Mycotoxins | |
Pesticides | |
Nerve agents | |
Bicyclic phosphates | |
Cholinergic neurotoxins | |
Other |