Codoxime (Codossima) is an opiate analogue that is a derivative of hydrocodone, where the 6-ketone group has been replaced by carboxymethyloxime. It has primarily antitussive effects[2] and was found to have moderate potential to cause dependence in animal studies.[3]
References
- ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
- ^ US granted 3153042, Jack Fishman, "Morphinone and Codeinone Derivatives", issued 13 October 1964, assigned to Mozes Juda Lowenstein
- ^ Jasinski DR, Martin WR (1967). "Assessment of the dependence-producing properties of dihydrocodeinone and codoxime". Clinical Pharmacology and Therapeutics. 8 (2): 266–70. doi:10.1002/cpt196782266. PMID 6021586. S2CID 36504901.