The Great Plains is a large, flat region of land in North America.
Great Plains may also refer to:
- Great Plains (Ohio band), a 1980s folk pop band
- Great Plains (Tennessee band), an American country music group
- "The Great Plains", a song by Scale the Summit from the album Carving Desert Canyons
- Great Plains Airlines, a defunct airline
- Great Hungarian Plain, a large plain spanning several countries in Eastern Europe
- Great Plains Software, a software company from Fargo, North Dakota that was acquired by Microsoft
- Microsoft Great Plains, accounting software now incorporated into Microsoft Dynamics GP
- Great Plains clothing brand, part of French Connection group
- Great Plains Aircraft Supply Company, an American company