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LY-393558 is a potent serotonin reuptake inhibitor and antagonist of the 5-HT1B, 5-HT1D, and 5-HT2A receptors. LY-393558 was also found to reduce serotonin-induced vasoconstriction, indicating that it may have therapeutic potential for the treatment of pulmonary hypertension.[1][2]

References

  1. ^ Mitchell SN, Greenslade RG, Cooper J (November 2001). "LY393558, a 5-hydroxytryptamine reuptake inhibitor and 5-HT(1B/1D) receptor antagonist: effects on extracellular levels of 5-hydroxytryptamine in the guinea pig and rat". European Journal of Pharmacology. 432 (1): 19–27. doi:10.1016/S0014-2999(01)01469-8. PMID 11734183.
  2. ^ Baranowska-Kuczko M, Kozłowska H, Schlicker E, Göthert M, MacLean MR, Kozłowski M, et al. (June 2020). "Reduction of the serotonin 5-HT1B and 5-HT2A receptor-mediated contraction of human pulmonary artery by the combined 5-HT1B receptor antagonist and serotonin transporter inhibitor LY393558". Pharmacological Reports. 72 (3): 756–762. doi:10.1007/s43440-020-00105-2. PMC 7329800. PMID 32333296.



source: https://en.wikipedia.org/wiki/LY-393558