Two-time defending champion Diede de Groot and her partner Aniek van Koot defeated Sabine Ellerbrock and Kgothatso Montjane in the final, 6–2, 6–0 to win the women's doubles wheelchair tennis title at the 2019 US Open. With the win, they completed the Grand Slam, and van Koot completed the triple career Grand Slam.
De Groot and Yui Kamiji were the defending champions, but did not compete together. Kamiji partnered Giulia Capocci, but was defeated in the semifinals by de Groot and van Koot.
Seeds
Diede de Groot / Aniek van Koot (champions)- Marjolein Buis /
Dana Mathewson (semifinals)
Draw
Key
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
Bracket
| Semifinals | Final | ||||||||||||
| 1 | Diede de Groot Aniek van Koot
| 6 | 7 | ||||||||||
 Giulia Capocci Yui Kamiji
| 2 | 5 | |||||||||||
| 1 | Diede de Groot Aniek van Koot
| 6 | 6 | ||||||||||
 Sabine Ellerbrock  Kgothatso Montjane
| 2 | 0 | |||||||||||
| Sabine Ellerbrock Kgothatso Montjane
| 6 | 4 | [10] | ||||||||||
| 2 | Marjolein Buis Dana Mathewson
| 1 | 6 | [6] | |||||||||