Five-time defending champion Diede de Groot defeated Yui Kamiji in the final, 6–2, 6–2 to win the women's singles wheelchair tennis title at the 2023 US Open.[1] With the win, de Groot completed the Grand Slam for a third consecutive year, and won a twelfth consecutive major singles title (an all-time record in any tennis discipline). This marked the seventh consecutive year where de Groot and Kamiji contested the final.
Seeds
Diede de Groot (champion)
Yui Kamiji (final)- Jiske Griffioen (semifinals, retired)
- Momoko Ohtani (semifinals)
Draw
Key
- Q = Qualifier
- WC = Wild card
- LL = Lucky loser
- Alt = Alternate
- SE = Special exempt
- PR = Protected ranking
- ITF = ITF entry
- JE = Junior exempt
- w/o = Walkover
- r = Retired
- d = Defaulted
- SR = Special ranking
Finals
| First round | Quarterfinals | Semifinals | Final | ||||||||||||||||||||||||
| 1 | Diede de Groot
| 6 | 6 | ||||||||||||||||||||||||
| WC |  Pauline Déroulède
| 2 | 0 | 1 | D de Groot
| 6 | 6 | ||||||||||||||||||||
 Lucy Shuker
| 4 | 6 | 6 | L Shuker
| 2 | 0 | |||||||||||||||||||||
| Manami Tanaka
| 6 | 3 | 4 | 1 | D de Groot
| 6 | 6 | ||||||||||||||||||||
| 4 | Momoko Ohtani
| 6 | 6 | 4 | M Ohtani
| 3 | 1 | ||||||||||||||||||||
 Zhu Zhenzhen
| 0 | 2 | 4 | M Ohtani
| 6 | 6 | |||||||||||||||||||||
 Kgothatso Montjane
| 6 | 6 | K Montjane
| 2 | 4 | ||||||||||||||||||||||
| WC |  María Florencia Moreno
| 2 | 1 | 1 | D de Groot
| 6 | 6 | ||||||||||||||||||||
| Aniek van Koot
| 6 | 6 | 2 | Y Kamiji
| 2 | 2 | |||||||||||||||||||||
| Lizzy de Greef
| 0 | 3 | A van Koot
| 4 | 3 | ||||||||||||||||||||||
| Shiori Funamizu
| 1 | 1 | 3 | J Griffioen
| 6 | 6 | |||||||||||||||||||||
| 3 | Jiske Griffioen
| 6 | 6 | 3 | J Griffioen
| 0 | 0r | ||||||||||||||||||||
 Angélica Bernal
| 6 | 6 | 2 | Y Kamiji
| 6 | 0 | |||||||||||||||||||||
 Katharina Krüger
| 4 | 1 | A Bernal
| 3 | 2 | ||||||||||||||||||||||
 Dana Mathewson
| 5 | 1 | 2 | Y Kamiji
| 6 | 6 | |||||||||||||||||||||
| 2 | Yui Kamiji
| 7 | 6 | ||||||||||||||||||||||||