The northern cottonmouth (Agkistrodon piscivorus) is a semiaquatic pit viper found in the southeastern United States.
The Florida cottonmouth (Agkistrodon conanti) is a similar semiaquatic pit viper found on the Florida peninsula and southern Georgia.
Cottonmouth may also refer to:
Medical symptom
- Xerostomia, or dry mouth, a medical symptom
Arts and entertainment
Fictional characters and elements
- Cottonmouth (Cornell Stokes), a supervillain in the Marvel Comics universe
- Cottonmouth (Burchell Clemens), a supervillain in the Marvel Comics universe
- O-Ren Ishii, or Cottonmouth, a character in the film Kill Bill: Volume 1
- Cottonmouth, a character in the 1978 film Convoy
- Cottonmouth, a fictional city and the setting for Manhunt 2
Music
- "Cotton Mouth", a 1972 song by the Doobie Brothers from Toulouse Street
- "Cottonmouth", a 1996 song by the Melvins
- "Cottonmouth", a 2007 song by Emanuel (band) from Black Earth Tiger
- "Cottonmouth", a 2008 song by Sam Sparro from Sam Sparro
- "Cottonmouth", a 2015 song by In Hearts Wake from Skydancer
- "Cottonmouth", a 2020 song by Tallah from Matriphagy
Television
- "Cottonmouth" (Justified), a 2011 episode of Justified