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PF-04745637 is a drug which acts as a potent and selective antagonist for the TRPA1 receptor, with an IC50 of 17nM, vs ~3μM at the related TRPV1 and TRPM channels. It has antiinflammatory effects and was developed as a potential treatment for conditions such as atopic dermatitis.[1]

References

  1. ^ Pryde DC, Marron B, West CG, Reister S, Amato G, Yoger K, et al. (2016). "The discovery of a potent series of carboxamide TRPA1 antagonists". MedChemComm. 7 (11): 2145–58. doi:10.1039/C6MD00387G.


source: https://en.wikipedia.org/wiki/PF-04745637