Puppi is an Italian surname. Notable people with the surname include:
- Francesco Puppi (born 1992), Italian long-distance runner
- Giampietro Puppi (1917–2006), Italian physicist
- Lionello Puppi (1931–2018), Italian art historian and politician
- Paulo R. Puppi (born 1999), writer
See also
- Puppis, a constellation in the southern sky