Up and Down, or variants, may refer to:
- Up and down, relative vertical direction
- Up and down, railway directions
Film and TV
- Up and Down (1965 film), an Italian film
- Up and Down (2004 film), a Czech film
- Up and Down, a spin-off of short film Luxo Jr., featured in Sesame Street
- Up & Down: Mukalil Oralundu, a 2013 Malayalam psychological thriller film
Games
- Up'n Down, a 1983 arcade game
- Up and down, a traveling violation in basketball
Music
Albums
- Up & Down (Horace Parlan album), 1961
- Up and Down (Opus album), 1984, or the title track
- Up and Down (Liane Carroll album), 2011
- Up & Down – The Party Album, by Vengaboys, 1998
- Up and Down, an EP by She Wants Revenge, 2009
Songs
- "Up and Down" (Vengaboys song), 1998
- "Up & Down" (Eddy Huntington song), 1987
- "Up & Down" (EXID song), 2014
- "Up and Down", a 1980 song by The Cars from Panorama
- "Up and Down", a 2021 song by Doja Cat from Planet Her
- "Up and Down", a 1958 song by Duane Eddy
- "Up and Down", a 1966 song by Eyes of Blue
- "Up and Down", a 1990 song by The High
- "Up and Down", a 1967 song by John Fred
- "Up and Down", a 1966 song by The McCoys
- "Up and Down", a 1982 song by Peter Combe from Songs for Little Kids
- "Up and Down", a 1974 song by The Shoes
- "Up and Down", a 1970 Sesame Street song by the Cookie Monster and Harry Monster
- "Up N' Down", a 2011 song by Britney Spears from Femme Fatale
- "Up/Down", a 2008 song by Jessica Mauboy
- "Up Down (Do This All Day)", a 2013 song by T-Pain
- "Up Down" (Morgan Wallen song), 2017