Chemical compound
ZCZ-011 is a positive allosteric modulator of the cannabinoid CB1 receptor.[1][2]
See also
References
- ^ Poklis JL, Clay DJ, Ignatowska-Jankowska BM, Zanato C, Ross RA, Greig IR, et al. (June 2015). "HPLC-MS-MS Determination of ZCZ-011, A Novel Pharmacological Tool for Investigation of the Cannabinoid Receptor in Mouse Brain Using Clean Screen FASt™ Column Extraction". Journal of Analytical Toxicology. 39 (5): 353–8. doi:10.1093/jat/bkv015. PMC 4542657. PMID 25737338.
- ^ Ignatowska-Jankowska BM, Baillie GL, Kinsey S, Crowe M, Ghosh S, Owens RA, et al. (December 2015). "A Cannabinoid CB1 Receptor-Positive Allosteric Modulator Reduces Neuropathic Pain in the Mouse with No Psychoactive Effects". Neuropsychopharmacology. 40 (13): 2948–59. doi:10.1038/npp.2015.148. PMC 4864630. PMID 26052038.
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Phytocannabinoids
(comparison) | | Cannabibutols | |
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| Cannabicyclols | |
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agonists /
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Non-classical
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| Hydrocarbons | |
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Indazole-3-
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Tetramethylcyclo-
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Receptor
(ligands) | | CB1Tooltip Cannabinoid receptor type 1 | Agonists
(abridged,
full list) | |
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| Antagonists | |
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| CB2Tooltip Cannabinoid receptor type 2 | | Agonists |
- 2-AG
- 2-AGE (noladin ether)
- 3,3'-Diindolylmethane
- 4-O-Methylhonokiol
- α-Amyrin · β-Amyrin
- A-796,260
- A-834,735
- A-836,339
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- AM-1241
- AM-2232
- Anandamide
- AZ-11713908
- Cannabinol
- Caryophyllene
- CB-13
- CBS-0550
- CP 55,940
- GW-405,833 (L-768,242)
- GW-842,166X
- HU-308
- JTE 7-31
- JWH-007
- JWH-015
- JWH-018
- JWH-73
- JWH-133
- L-759,633
- L-759,656
- Lenabasum (anabasum)
- Magnolol
- MDA-19
- Nabitan
- NADA
- Olorinab (APD-371)
- PF-03550096
- S-444,823
- SER-601
- Serinolamide A
- UR-144
- Tedalinab
- THC (dronabinol)
- THCV
- Tetrahydromagnolol
- Virodhamine
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NAGly
(GPR18) | |
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| GPR55 | |
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| GPR119 | |
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Transporter
(modulators) | | eCBTsTooltip Endocannabinoid transporter | |
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Enzyme
(modulators) | |
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| Others |
- Others: 2-PG (directly potentiates activity of 2-AG at CB1 receptor)
- ARN-272 (FAAH-like anandamide transporter inhibitor)
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